allemand anglais arabe bulgare chinois coréen croate danois espagnol estonien finnois français grec hébreu hindi hongrois islandais indonésien italien japonais letton lituanien malgache néerlandais norvégien persan polonais portugais roumain russe serbe slovaque slovène suédois tchèque thai turc vietnamien
allemand anglais arabe bulgare chinois coréen croate danois espagnol estonien finnois français grec hébreu hindi hongrois islandais indonésien italien japonais letton lituanien malgache néerlandais norvégien persan polonais portugais roumain russe serbe slovaque slovène suédois tchèque thai turc vietnamien

définition - Coccidioidomycosis

coccidioidomycosis (n.)

1.an infection of the lungs and skin characterized by excessive sputum and nodules

Coccidioidomycosis (n.)

1.(MeSH)Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN.

   Publicité ▼

définition (complément)

voir la définition de Wikipedia

synonymes - Coccidioidomycosis

   Publicité ▼


dictionnaire analogique


Coccidioidomycosis (n.) [MeSH]

coccidioidomycosis (n.)



Classification and external resources

Histopathological changes in a case of coccidioidomycosis of the lung showing a large fibrocaseous nodule.
ICD-10 B38
ICD-9 114
MedlinePlus 001322
eMedicine med/103 ped/423
MeSH D003047

Coccidioidomycosis (play /kɑːkˌsɪdiɔɪdmˈksɪs/, commonly known as "Valley fever"[1], as well as "California fever"[1], "Desert rheumatism"[1], and "San Joaquin Valley fever"[1]) is a fungal disease caused by Coccidioides immitis or C. posadasii.[2] It is endemic in certain parts of Arizona, California, Nevada, New Mexico, Texas, Utah and northwestern Mexico.[3]

C. immitis resides in the soil in certain parts of the southwestern United States, northern Mexico, and parts of Central and South America.[4] It is dormant during long dry spells, then develops as a mold with long filaments that break off into airborne spores when the rains come. The spores, known as arthroconidia, are swept into the air by disruption of the soil, such as during construction, farming, or an earthquake.[5] Infection is caused by inhalation of the particles. The disease is not transmitted from person to person. The infection ordinarily resolves leaving the patient with a specific immunity to re-infection.[6]C. immitis is a dimorphic saprophytic organism that grows as a mycelium in the soil and produces a spherule form in the host organism.



The disease is usually mild, with flu-like symptoms and rashes. The Mayo Clinic estimates that half the population in some affected areas have suffered from the disease. On occasion, those particularly susceptible may develop a serious or even fatal illness. Serious complications include severe pneumonia, lung nodules, and disseminated disease, where the fungus spreads throughout the body. The disseminated form of valley fever can devastate the body, causing skin ulcers, abscesses, bone lesions, severe joint pain, heart inflammation, urinary tract problems, meningitis, and often death. In order of decreasing risk, people of Filipino, African, Native American, Hispanic, and Asian descent are susceptible to the disseminated form of the disease.[7] Men and pregnant women, and people with weakened immune systems (as from AIDS) are more susceptible than non-pregnant women.

It has been known to infect humans, cattle, deer, dogs, elk, fish, mules, livestock, apes, kangaroos, wallabies, tigers, bears, badgers, otters and marine mammals.[8]

Symptomatic infection (40% of cases) usually presents as an influenza-like illness with fever, cough, headaches, rash, and myalgia (muscle pain).[9] Some patients fail to recover and develop chronic pulmonary infection or widespread disseminated infection (affecting meninges, soft tissues, joints, and bone). Severe pulmonary disease may develop in HIV-infected persons.[10]

An additional risk is that health care providers who are unfamiliar with it or are unaware that the patient has been exposed to it may misdiagnose it as cancer and subject the patient to unnecessary surgery.[11]

  Geographic distribution of coccidioidomycosis.


Coccidioidomycosis may be divided into the following types:[12]:314-316

  Incidence (North America)

California state prisons, as far back as 1919, have been particularly affected by Coccidioidomycosis. In 2005 and 2006, the Pleasant Valley State Prison near Coalinga and Avenal State Prison near Avenal on the western side of the San Joaquin Valley had the highest incidence in 2005, of at least 3,000 per 100,000.[13]

Incidence varies widely across the west and southwest. In Arizona, for instance, in 2007, there were 3,450 cases in Maricopa County, which in 2007 had an estimated population of 3,880,181[14] for an incidence of approximately 1 in 1,125.[15] In contrast, though southern New Mexico is considered an endemic region, there were 35 cases in the entire state in 2008, and 23 in 2007,[15] in a region that had an estimated 2008 population of 1,984,356[16] for an incidence of approximately 1 in 56,695. Infection rates vary greatly by county, and although population density is important, so are other factors that have not been proven yet. Greater construction activity may disturb spores in the soil. In addition, the effect of altitude on fungi growth and morphology has not been studied, and altitude can range from sea level to 10,000 feet or higher across California, Arizona, Texas and New Mexico.

In California from 2000 to 2007, there were 16,970 reported cases (5.9 per 100,000 people) and 752 deaths (0.26 per 100,000 people) with the highest incidence in the San Joaquin Valley (44.1 per 100,000).[17]

  Biological warfare

C. immitis was investigated by the United States during the 1950s and 1960s as a potential biological weapon.[citation needed] The Cash strain received the military symbol OC, and original hopes were for its use as an incapacitant. As medical epidemiology later made clear, OC would have lethal effects on several segments of the population, so it was later considered a lethal agent. It was never standardized, and beyond a few field trials, it was never weaponized. Most military work on OC was on vaccines by the mid-1960s. It is still on the CDC's list of select agents however.[18]

  Diagnostic test

The fungal infection can be demonstrated by microscopic detection of diagnostic cells in body fluids, exudates, sputum and biopsy-tissue. With specific nucleotide primers C.immitis DNA can be amplified by PCR. It can also be detected in culture by morphological identification or by using molecular probes that hybridize with C.immitis RNA. An indirect demonstration of fungal infection can be achieved also by serologic analysis detecting fungal antigen or host antibody produced against the fungus.


There are no published prospective studies that examine optimal antifungal therapy for coccidioidomycosis. Mild cases often do not require treatment. Oral Fluconazole and intravenous Amphotericin B are used in progressive or disseminated disease, or in which patients are immunocompromised. Alternatively, itraconazole or ketoconazole may be used.[19] Posaconazole and voriconazole have also been used. A face mask would be a very good thing to wear when the Coccidioidomycosis is active.

  Additional images

  See also


  1. ^ a b c d Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ Walsh TJ, Dixon DM (1996). Spectrum of Mycoses. In: Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. (via NCBI Bookshelf). 
  3. ^ Hector R, Laniado-Laborin R (2005). "Coccidioidomycosis—A Fungal Disease of the Americas". PLoS Med 2 (1): e2. DOI:10.1371/journal.pmed.0020002. PMC 545195. PMID 15696207. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545195. 
  4. ^ http://www.mayoclinic.com/print/valley-fever/DS00695/DSECTION=all&METHOD=print
  5. ^ Schneider E, Hajjeh RA, Spiegel RA, et al. (1997). "A coccidioidomycosis outbreak following the Northridge, Calif, earthquake". JAMA 277 (11): 904–8. DOI:10.1001/jama.277.11.904. PMID 9062329 
  6. ^ http://www.mycology.adelaide.edu.au/Mycoses/Dimorphic_systemic/Coccidioidomycosis/
  7. ^ http://www.merck.com/mmpe/sec14/ch180/ch180f.html
  8. ^ Valley Fever Center for Excellence | url = http://www.vfce.arizona.edu/ValleyFeverInPets/VFID-other.aspx
  9. ^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 680–83. ISBN 0-8385-8529-9. 
  10. ^ Ampel N (2005). "Coccidioidomycosis in persons infected with HIV type 1". Clin Infect Dis 41 (8): 1174–8. DOI:10.1086/444502. PMID 16163637. 
  11. ^ Chen, Karl T. K. (1993). "Cytodiagnostic pitfalls in pulmonary coccidioidomycosis". Diagn Cytopathol 12 (2): 177–180. DOI:10.1002/dc.2840120220. PMID 7774502. 
  12. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  13. ^ http://www.blackwell-synergy.com/doi/abs/10.1196/annals.1406.011
  14. ^ U.S. Census Bureau, State & County QuickFacts
  15. ^ a b http://www.azdhs.gov/phs/oids/pdf/countycases2007.pdf
  16. ^ New Mexico Intercensal Population Estimates from the U.S. Census Bureau [1]
  17. ^ Morbidity and Mortality Weekly Report 58;5 105-109
  18. ^ http://www.cdc.gov/od/sap/docs/salist.pdf
  19. ^ Barron MA and Madinger NE (November 18, 2008). "Opportunistic Fungal Infections, Part 3: Cryptococcosis, Histoplasmosis, Coccidioidomycosis, and Emerging Mould Infections". Infections in Medicine. http://www.consultantlive.com/infection/article/1145625/1404367. 

  External links



Toutes les traductions de Coccidioidomycosis

Contenu de sensagent

  • définitions
  • synonymes
  • antonymes
  • encyclopédie

  • definition
  • synonym

Dictionnaire et traducteur pour mobile

⇨ Nouveau : sensagent est maintenant disponible sur votre mobile

   Publicité ▼

sensagent's office

Raccourcis et gadgets. Gratuit.

* Raccourci Windows : sensagent.

* Widget Vista : sensagent.

dictionnaire et traducteur pour sites web


Une fenêtre (pop-into) d'information (contenu principal de Sensagent) est invoquée un double-clic sur n'importe quel mot de votre page web. LA fenêtre fournit des explications et des traductions contextuelles, c'est-à-dire sans obliger votre visiteur à quitter votre page web !

Essayer ici, télécharger le code;


Avec la boîte de recherches Sensagent, les visiteurs de votre site peuvent également accéder à une information de référence pertinente parmi plus de 5 millions de pages web indexées sur Sensagent.com. Vous pouvez Choisir la taille qui convient le mieux à votre site et adapter la charte graphique.

Solution commerce électronique

Augmenter le contenu de votre site

Ajouter de nouveaux contenus Add à votre site depuis Sensagent par XML.

Parcourir les produits et les annonces

Obtenir des informations en XML pour filtrer le meilleur contenu.

Indexer des images et définir des méta-données

Fixer la signification de chaque méta-donnée (multilingue).

Renseignements suite à un email de description de votre projet.

Jeux de lettres

Les jeux de lettre français sont :
○   Anagrammes
○   jokers, mots-croisés
○   Lettris
○   Boggle.


Lettris est un jeu de lettres gravitationnelles proche de Tetris. Chaque lettre qui apparaît descend ; il faut placer les lettres de telle manière que des mots se forment (gauche, droit, haut et bas) et que de la place soit libérée.


Il s'agit en 3 minutes de trouver le plus grand nombre de mots possibles de trois lettres et plus dans une grille de 16 lettres. Il est aussi possible de jouer avec la grille de 25 cases. Les lettres doivent être adjacentes et les mots les plus longs sont les meilleurs. Participer au concours et enregistrer votre nom dans la liste de meilleurs joueurs ! Jouer

Dictionnaire de la langue française
Principales Références

La plupart des définitions du français sont proposées par SenseGates et comportent un approfondissement avec Littré et plusieurs auteurs techniques spécialisés.
Le dictionnaire des synonymes est surtout dérivé du dictionnaire intégral (TID).
L'encyclopédie française bénéficie de la licence Wikipedia (GNU).


Les jeux de lettres anagramme, mot-croisé, joker, Lettris et Boggle sont proposés par Memodata.
Le service web Alexandria est motorisé par Memodata pour faciliter les recherches sur Ebay.
La SensagentBox est offerte par sensAgent.


Changer la langue cible pour obtenir des traductions.
Astuce: parcourir les champs sémantiques du dictionnaire analogique en plusieurs langues pour mieux apprendre avec sensagent.

Dernières recherches dans le dictionnaire :

2535 visiteurs en ligne

calculé en 0,078s

Je voudrais signaler :
section :
une faute d'orthographe ou de grammaire
un contenu abusif (raciste, pornographique, diffamatoire)
une violation de copyright
une erreur
un manque
merci de préciser :

Mon compte



   Publicité ▼